Synthesis of a tyrosine “homologue” of lysine‐vasopressin
- 1 January 1960
- journal article
- research article
- Published by Wiley in Recueil des Travaux Chimiques des Pays-Bas
- Vol. 79 (10) , 1034-1038
- https://doi.org/10.1002/recl.19600791005
Abstract
The synthesis is described of the protected linear decapeptide: N‐benzyloxycarbonyl‐S‐benzyl‐L‐cysteinyl‐L‐tyrosyl‐L‐tyrosyl‐L‐phenylalanyl‐L‐glutaminyl‐L‐asparaginyl‐S‐benzyl‐L‐cysteinyl‐L‐prolyl‐N6‐tosyl‐L‐lysylglycineamide (II, Fig. 2).Removal of the blocking groups from II, followed by oxidation, yielded a preparation believed to contain a “homologue” of lysine‐vasopressin with two consecutive molecules of tyrosine instead of one (Fig. 1, n = 2).Keywords
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