Prevalence of anti‐FVIII antibodies in severe haemophilia A patients with inversion of intron 22

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Abstract
The aim of our study was to investigate whether haemophilia A patients with inversion of intron 22 are at high risk for non‐inhibitory anti‐FVIII antibodies development detected by ELISA. It is known that patients with severe forms of haemophilia A are more likely to develop anti‐FVIII antibodies. The incidence of inhibitory anti‐FVIII antibodies in patients with factor VIII gene inversion has been extensively evaluated, but if this defect has to be considered a predisposing factor is still debatable. Non‐inhibitory anti‐FVIII antibodies are attracting interest, due to the potential influence on FVIII half‐life. Our data show that FVIII gene inversion was a major predisposing factor for anti‐FVIII antibodies development.

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