Invasive Disease Due to Streptococcus pneumoniae in an Area with a High Rate of Relative Penicillin Resistance

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Abstract
During 1984 we conducted a population-based survey of culture-confirmed invasive disease due to Streptococcus pneumoniae among persons who lived in the Oklahoma City, Oklahoma, metropolitan area (population, 846,000) through the 20 clinical laboratories in the area. There were 139 residents identified with invasive pneumococcal disease (11 with meningitis and 128 with other bacteremic infections), for an infection rate of 16.4 per 100,000 population (meningitis, 1.3 cases per 100,000; other bacteremias, 15.1 cases per 100,000). Cases peaked in January-May and December(75% of cases). Rates were highest among infants <12 months old (97 cases per 100,000) and persons ⩾80 years old (87 cases per 100,000. Seventeen (12.2%) of the pneumococcal isolates were relatively penicillin resistant. These isolates were most prevalent among elderly persons ⩾70 years old (six [17.6%] of 34)and young children 0–4 yearsold (7 [15.9%] of 44) compared with persons 5–69 years old (four [6.6%] of 61).