RENAL CLEARANCES OF IOPAX, NEOIOPAX AND SKIODAN IN MAN

Abstract
The organic iodine compounds, iopax, neoiopax. and skiodan. are ex- creted in part by the renal tubules in the human kidney. As in the case of other substances excreted by tubular activity, the clearances are depressed as the plasma conc. is elevated. All these substances, when present in increasing plasma concs., progressively depress the phenol red clearance. The greater the tubular clearance of the organic iodine compound, the greater is the capacity to depress the phenol red clearance. These substances are probably all excreted by a common cellular mechanism, and enter into quantitative competition for that mechanism.

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