Effects of Slaframine on Ruminant Digestive Function: Ruminal Motility in Sheep and Cattle

Publisher Website
Google Scholar
Abstract
Effect of purified slaframine (SF; 1-acetoxy-6-aminooctahydroindolizine), a parasympathomimetic secretagogue isolated from Rhizoctonia leguminicola, on ruminal motility was investigated in cattle and sheep. In trial 1, four ruminal cannulated wethers, fed a pelleted concentrate and hay diet, were injected intramuscularly with 0, 12, 24 and 48 µg SF/kg body weight (BW) in a 4 × 4 Latin-square design. Ruminal motility was recorded 1 h before and 1 to 2 h and 3 to 4 h after SF administration by measuring pressure changes exerted upon a fluid-filled, open-tipped catheter inserted into the dorsal sac of the rumen. The frequencies of both primary and secondary ruminal contractions were decreased as much as 20 to 78% with SF (P<.05) depending upon the dosage level and time after administration. In trial 2, three ruminal-cannulated steers fed a concentrated diet were injected intramuscularly with 0, 12 and 24 µg SF/kg BW in a 3 × 3 Latin-square design. A water-filled balloon inserted into the cranial sac of the rumen was used to measure ruminal pressure changes 1 h before and 1 to 2 h, 3 to 4 h and 7 to 8 h after SF administration. Frequency of primary and secondary ruminal contractions decreased with SF as much as 27 to 64% depending on the dosage level and time after administration. The frequency of secondary contractions increased 28% (P<.05) as compared with control during the 7 to 8 h after administration. Because of the known stimulatory effect of SF on salivation, its actions upon ruminal motility suggest that different populations of cholinergic receptors exist in ruminant salivary glands and ruminal smooth muscle. Copyright © 1986. American Society of Animal Science . Copyright 1986 by American Society of Animal Science.

This publication has 0 references indexed in Scilit: