Mismatch repair as an important source of new mutations in non-dividing cells
- 1 April 1996
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 52 (4) , 357-363
- https://doi.org/10.1007/bf01919541
Abstract
This paper describes a mechanism which permits somatic cells to generate random mutations in the complete absence of cell proliferation. Knowledge of the existence of this mechanism should provide us with the basis for a better understanding of a number of important biological phenomena, and in particular may help to explain the origins of many human cancers.Keywords
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