Synthesis of Cyclic (α2β)-Tripeptides as Potential Peptide Turn Mimetics
- 1 June 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (13) , 2173-2176
- https://doi.org/10.1021/ol025988b
Abstract
The solid-supported synthesis followed by cyclization in solution of cyclic (α2β)-tripeptides, potential peptide β-turn mimetics, is described. The cyclization takes advantage of facilitating the rotation between trans- and cis-rotamers of two amide bonds. The method is amenable to combinatorial approaches as is illustrated by the synthesis of a small array of cyclic (α2β)-tripeptides.Keywords
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