The Combined Use of Fibrin Film and Clot in End-to-End Union of Nerves

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Abstract
A thin smooth film of fibrin is impregnated with thrombin, surfaced with fibrinogen, and applied to the apposed nerve stumps without the use of thread sutures. In addition to maintaining the apposition of the stumps, the film encloses nerve stumps and nerve wound in a continuous channel, and is transparent, allowing observation of the stumps throughout the operation. Since the fibrin adhesive does not develop full strength until full envelopment has been accomplished and the clot has "set," stay sutures may be necessary in tensions greater than those involved in primary suture of the rabbit sciatic. Thickness of film and layer of fibrinogen, dryness of film and stumps, and possibly other factors affect the tensile strength of the nerve-to-film union.