Families of H/ACA ncRNA molecules in Trypanosomatids
Open Access
- 1 September 2009
- journal article
- Published by Taylor & Francis in RNA Biology
- Vol. 6 (4) , 370-374
- https://doi.org/10.4161/rna.6.4.9270
Abstract
H/ACA molecules are small nucleolar RNAs (snoRNAs) that guide the conversion of a uridine into a pseudouridine. This modification is crucial for ribosomal RNA (rRNA) function. In addition, H/ACA RNA also function in ribosomal RNA processing. Unlike the double hairpin structure of H/ACA molecules in other organisms, H/ACA molecules in Trypanosomes have a single hairpin structure. Here we describe the repertoire of H/ACA molecules of the 46 published of Trypanosoma brucei, as well as identify the orthologous counterparts in other Trypanosomatids enlarging the H/ACA collection in this family to over 300.Keywords
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