PLASMA AND SYNOVIAL-FLUID CONCENTRATIONS OF ISOXICAM IN MENISCECTOMIZED PATIENTS

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 11  (8) , 517-521
Abstract
Concentrations of isoxicam in the plasma and synovial fluid of 7 patients were investigated by means of high-pressure liquid chromatography. The samples were collected after 7 days'' treatment with a single 200 mg isoxicam capsule taken each morning. A highly significant correlation was found (r = 0.82; p < 0.05) between isoxicam concentrations in the plasma and in the synovial fluid. The mean concentration (.+-. s.d.) was 25.54 .+-. 10.91 .mu.g/ml in the plasma and 17.47 .+-. 6.54 .mu.g/ml in the synovial fluid; the ratio between isoxicam concentrations in the synovial fluid and in the plasma was 71.06% .+-. 18.83.