Separation of serotonin from catechols by capillary zone electrophoresis with electrochemical detection
- 15 January 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 61 (2) , 98-100
- https://doi.org/10.1021/ac00177a004
Abstract
Capillary zone electrophoresis with electrochemical detection is demonstrated with columns having only 9-.mu.m inner diameter. Amperometric detection limits of 0.7 amol are reported for serotonin. The difficult problem of resolving serotonin and dopamine .sbd. two neurotransmitters of interest having similar electrophoretic mobilities .sbd. is addressed by chemical means to improve selectivity. These include buffer modification with 2-propanol and a system employing borate complexation of the catechol in combination with sodium dodecyl sulfate micelles.This publication has 2 references indexed in Scilit:
- Capillary chromatography in the condensed mobile phases: From the concepts to analytically useful separations and measurementsJournal of High Resolution Chromatography, 1987
- Carbon-ring electrodes with 1-.mu.m tip diameterAnalytical Chemistry, 1986