Role of THAM in Protecting Mice Against Convulsive Episodes Caused by Exposure to Oxygen Under High Pressure
- 1 February 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 112 (2) , 427-430
- https://doi.org/10.3181/00379727-112-28065
Abstract
Summary THAM, 0.3 M, protected mice from the CNS symptoms of oxygen toxicity at 4 atm. This was shown by the prolonged time required before onset of seizure activity. The same concentration of THAM did not protect at 6 atm. Addition of low concentrations of KCl and NaCl appeared to reverse this protection. A mixture of THAM, 0.6 M, and 0.15 M KCl is lethal to mice.Keywords
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