Increase of Brain Oxidative Stress in Mild Cognitive Impairment
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Open Access
- 1 June 2002
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 59 (6) , 972-976
- https://doi.org/10.1001/archneur.59.6.972
Abstract
ALZHEIMER DISEASE (AD) is the most common cause of dementia in the elderly and may have a long stage of neuropathological changes and cognitive decline before it is diagnosed.1 An increasing number of studies clearly indicate that the onset of AD is typically preceded by an interim phase known as mild cognitive impairment (MCI).2,3 In its amnestic version, MCI is characterized primarily by a memory deficit without clinically meaningful functional impairment.4 Typically, the onset of MCI is marked by a measurable memory loss that is abnormal for an individual's age and education and is corroborated by an informant.5Keywords
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