Long Term Effects of Artificial Ventilation in Neonates
- 21 January 1987
- journal article
- research article
- Published by Wiley in Acta Paediatrica
- Vol. 76 (1) , 24-29
- https://doi.org/10.1111/j.1651-2227.1987.tb10409.x
Abstract
In order to evaluate long term effects of artificial ventilation, 27 children, who had been ventilated for more than five days in their neonatal period, were reinvestigated at school age. In 5 of them bronchopulmonary dysplasia had been diagnosed. Seven had more than 10 upper respiratory tract infections per year and 9 had recurrent obstructive airway disease. On pulmonary function testing (n = 23) 19% showed some airway obstruction, and in 43% bronchial hyperreactivity was found by bronchial provocation with histamine. There was a significant correlation (p < 0.05) between bronchial hyperreactivity and the duration of neonatal ventilation. The degree of hyperreactivity (PC20, FEV1) also correlated with birth weight (p < 0.005) and gestational age (p < 0.02). It is concluded that prolonged neonatal ventilation might be followed by bronchial hyperreactivity, especially in the small and premature newborn.Keywords
This publication has 18 references indexed in Scilit:
- Bronchial sensitivity to inhaled histamine in healthy, nonatopic childrenPediatric Pulmonology, 1986
- The Long-Term Pulmonary Sequelae of Prematurity: The Role of Familial Airway Hyperreactivity and the Respiratory Distress SyndromeNew England Journal of Medicine, 1985
- SEVERE BRONCHOPULMONARY DYSPLASIA: A RETROSPECTIVE REVIEWActa Paediatrica, 1983
- Pulmonary sequelae of neonatal respiratory distress in very low birthweight infants: a clinical and physiological study.Archives of Disease in Childhood, 1982
- Growth and development in children recovering from bronchopulmonary dysplasiaThe Journal of Pediatrics, 1981
- Bronchial reactivity to inhaled histamine: a method and clinical surveyClinical and Experimental Allergy, 1977
- PULMONARY MECHANICS IN INFANTS SURVIVING SEVERE NEONATAL RESPIRATORY INSUFFICIENCYActa Paediatrica, 1975
- Long-term follow-up of severe respiratory distress syndrome treated with IPPBThe Journal of Pediatrics, 1974
- Prognosis of children surviving with the aid of mechanical ventilation in the newborn periodThe Journal of Pediatrics, 1974
- Acute pulmonary X-ray changes in hyaline membrane disease treated with artificial ventilation and positive end-expiratory pressure (PEP)Pediatric Radiology, 1973