A phase II trial of cyclophosphamide and adriamycin in refractory squamous cell carcinoma of the head and neck

Abstract
A phase II trial of cyclophosphamide and adriamycin was carried out in 26 patients with recurrent squamous cell carcinoma of the head and neck, previously treated with cis-diamminedichloroplatinum-based regimens. The overall response rate was 46% (12/26 patients) with the median duration of response being 6.5 mo. Cyclophosphamide and adrimycin is an active combination in patients with previously treated squamous cell carcinoma of the head and neck.