Prolonged Colchicine Treatment in Four Patients with Amyloidosis

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Abstract
The natural clinical course of 4 patients with systemic amyloidosis was favorably altered by continuous colchicine therapy. One patient had primary amyloidosis, and the other 3 suffered from amyloidosis of familial Mediterranean fever. All had a nephrotic syndrome and 1 showed features of intestinal malabsorption. The institution of colchicine therapy was followed by a gradual remission of the nephrotic syndrome, a rise of serum albumin to normal values, a slight improvement of renal function and regression of the intestinal malabsorption. This pattern has remained steady during an observation period of 30 mo.

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