PROSTAGLANDIN AS AN EFFECTIVE ANTIREJECTION THERAPY IN RAT RENAL ALLOGRAFT RECIPIENTS

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Abstract
Because adenylate cyclase activators such as prostaglandin E1 elevate lymphocytic cAMP and inhibit T cell proliferation and the effector function of cytotoxic T cells in vitro, the efficacy of 15(S)-15-methyl prostaglandin E1, a prostaglandin derivative with a prolonged biologic half-life was tested. Treatment with this agent resulted in a near complete protection of renal grafts from immunologic damage in rats, despite withholding therapy until day 4 following transplantation.