A New Route to 2,5-Diamino-4,6-dichloropyrimidine, A Key Precursor of 9-Substituted Guanines
- 1 January 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1990 (07) , 587-589
- https://doi.org/10.1055/s-1990-26949
Abstract
An improved synthesis of 2,5-diamino-4,6-dihydroxypyrimidine (7) is reported. The direct chlorination of 7 provides the shortest (2 step) synthesis of 2,5-diamino-4,6-dichloropyrimidine (5) reported to date. The procedure described here affords an easy approach to 5, a key intermediate to various 9-substituted guanines.Keywords
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