Preparation, characterization, and properties of polylactide (PLA)–poly(ethylene glycol) (PEG) copolymers: A potential drug carrier
- 5 January 1990
- journal article
- research article
- Published by Wiley in Journal of Applied Polymer Science
- Vol. 39 (1) , 1-9
- https://doi.org/10.1002/app.1990.070390101
Abstract
Polylactide (PLA)‐poly(ethylene glycol) (PEG) copolymers were synthesized from polyethylene glycol and D,L‐lactide using low toxic stannous octoate as catalyst at 180°C by bulk polymerization. The copolymers were characterized by GPC, IR, and 13C‐NMR. A full assignment NMR spectrum is presented. The physical, drug release, and biodegradable properties in vitro of PLA–PEG copolymers were investigated. The result indicates that the rates of drug release and biodegradation could be tailored by adjusting polymer composition. This amorphous material might be used as a drug carrier in medical applications.Keywords
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