COMPARISON OF TRITIATED-THYMIDINE LABELING AND SUICIDE INDEXES IN ACUTE NONLYMPHOCYTIC LEUKEMIA
- 1 January 1978
- journal article
- research article
- Vol. 38 (11) , 3681-3684
Abstract
Leukemic cells were obtained from the bone marrow or peripheral blood of patients with acute myelocytic leukemia or one of its variants. The tritiated thymidine labeling index of the leukemic cells and the suicide index of the cells that produce clusters in vitro were compared. The suicide index was 5 times greater than the labeling index, demonstrating the presence of a highly proliferative subpopulation of leukemic cells (in vitro colony-forming unit) among the relatively slowly proliferating leukemic cells. Since the leukemic in vitro colony-forming unit appears to be the progenitor of the recognizable leukemic cell population, the proliferative characteristics of the recognizable leukemic cells may not be reflective of that of leukemic stem cells.This publication has 4 references indexed in Scilit:
- MURINE MYELOID-LEUKEMIA - COLONY FORMATION INVITRO1978
- ADRIAMYCIN-CYTOSINE ARABINOSIDE THERAPY FOR ADULT ACUTE MYELOCYTIC-LEUKEMIA1977
- SEPARATION OF LEUKEMIC-CELLS INTO PROLIFERATIVE AND QUIESCENT SUBPOPULATIONS BY CENTRIFUGAL ELUTRIATION1977
- Studies of Cellular Proliferation in Human Leukemia. I. Estimation of Growth Rates of Leukemic and Normal Hematopoietic Cells in Two Adults with Acute Leukemia Given Single Injections of Tritiated Thymidine *Journal of Clinical Investigation, 1967