Plasma Adrenomedullin and Natriuretic Peptides in Patients with Essential or Malignant Hypertension.
Open Access
- 1 January 1999
- journal article
- research article
- Published by Japanese Society of Hypertension in Hypertension Research
- Vol. 22 (1) , 61-65
- https://doi.org/10.1291/hypres.22.61
Abstract
Adrenomedullin (AM), a potent vasodilator and natriuretic peptide, is found in human blood. To investigate the pathophysiological role of AM in essential and malignant hypertension (EHT and MHT), we measured the plasma concentrations of AM in patients with EHT of WHO stage I or II (n=42) and in those with MHT (n=9) by a specific radioimmunoassay, and compared these concentrations with those in normotensive controls (n=46). The plasma concentrations of atrial and brain natriuretic peptides (ANP and BNP) in these subjects were also measured by immunoradiometric assays, and their relations to plasma AM were examined. The plasma AM level in the EHT patients (7.15±0.21pmol/l, mean±SEM) was significantly (pp r=0.44) and diastolic (r=0.46) blood pressures, but also with the plasma levels of ANP (r=0.43) and BNP (r=0.43). The elevated plasma concentration of AM in the MHT patients decreased significantly (pHypertens Res 1999; 22: 61-65)Keywords
This publication has 0 references indexed in Scilit: