Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2
- 18 December 1992
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 258 (5090) , 1955-1957
- https://doi.org/10.1126/science.1470921
Abstract
Programmed cell death is a physiological process that eliminates unwanted cells. The bcl-2 gene regulates programmed cell death in mammalian cells, but the way it functions is not known. Expression of the human bcl-2 gene in the nematode Caenorhabditis elegans reduced the number of programmed cell deaths, suggesting that the mechanism of programmed cell death controlled by bcl-2 in humans is the same as that in nematodes.Keywords
This publication has 24 references indexed in Scilit:
- Post-embryonic cell lineages of the nematode, Caenorhabditis elegansPublished by Elsevier ,2004
- Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killingInternational Immunology, 1992
- Mechanisms and Functions of Cell DeathAnnual Review of Cell Biology, 1991
- Mechanisms And Functions Of Cell DeathAnnual Review of Cell and Developmental Biology, 1991
- Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell deathNature, 1990
- The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell deathDevelopmental Biology, 1990
- A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegansGene, 1990
- Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocationCell, 1986
- Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18Cell, 1985
- Mutations Affecting Programmed Cell Deaths in the Nematode Caenorhabditis elegans sScience, 1983