Synthesis of a Ketone Analogue of Biotin via the Intramolecular Pauson−Khand Reaction
- 1 September 2006
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 8 (20) , 4593-4595
- https://doi.org/10.1021/ol061862t
Abstract
We report an improved synthesis of 5-(5-oxohexahydrocyclopenta[c]thiophen-1-yl)pentanoic acid (ketone biotin, 1) based on the intramolecular Pauson−Khand cyclization. The synthesis proceeds in eight steps and in 2.7% overall yield from cyclohexene.Keywords
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