Catabolism of serum gamma G-globulins in a cancer patient and a normal volunteer.

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Abstract
The survival of radiolodlne-labelled serum gammaG-globulins was determined in a normal volunteer and in a cancer patient over a period of 9 weeks. Different electro-phoretic fractions of the gammaG-globulin broke down at different rates. This catabolic heterogeneity of the gammaG-globulins gave rise to an apparent time dependence of the observed half-life value. Mean half-life values, as measured over the entire 9-week period, were 25 days for gammaG-globulins in the normal volunteer and 18 days for the same gammaG-globulin preparation In the cancer patient. The breakdown rates In both Individuals appeared to be independent of the source of the labelled gammaG-globulins.