Indinavir Population Pharmacokinetics in Plasma and Cerebrospinal Fluid
- 1 August 2000
- journal article
- clinical trial
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 44 (8) , 2173-2175
- https://doi.org/10.1128/aac.44.8.2173-2175.2000
Abstract
Plasma and cerebrospinal fluid (CSF) indinavir concentrations were measured by high-performance liquid chromatography. The median concentration in plasma exceeded that in CSF 10-fold. The modeled CSF curve was flat at 155 nM, and the estimated ratio of the areas under the CSF and plasma concentration-time curves was 6%. We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical 95% inhibitory concentration range.Keywords
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