Structural and Genetic Studies on Chicken 7S Immunoglobulin Allotypes
Open Access
- 1 October 1977
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 119 (4) , 1218-1222
- https://doi.org/10.4049/jimmunol.119.4.1218
Abstract
A survey of 47 inbred or partially inbred chicken lines derived from five sources in the United States and Europe revealed considerable genetic polymorphism in the structural gene (CS-1) responsible for the production of the predominant chicken 7S Ig heavy chain. A minimum of 10 alleles of the CS-1 gene were detected as unique combinations or phenogroups of CS-1 specificities. A system of nomenclature for CS-1 alleles was developed and six homozygous lines were designated as prototype lines. The remaining four CS-1 alleles occurred only in lines that were polymorphic for 7S Ig allotypic specificities.Keywords
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