A variant of human transferrin with abnormal properties
- 1 January 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 201 (1) , 19-26
- https://doi.org/10.1042/bj2010019
Abstract
Screening of human serum samples by polyacrylamide-gel electrophoresis in the presence of 6 M-urea revealed an individual who is heterozygous for a variant transferrin. The variant transferrin is able to bind two atoms of iron, but the iron in the C-terminal binding site is bound abnormally, as judged by its spectral properties, and is dissociated from the protein on electrophoresis in the presence of 6 M-urea. The iron-free C-terminal domain of the variant protein is less stable than normal to thermal and urea denaturation. Structural changes in the variant protein have not yet been characterized.This publication has 8 references indexed in Scilit:
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