Subpopulations of CD34‐positive haemopoietic progenitors in fetal blood
- 1 July 1994
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 87 (3) , 634-636
- https://doi.org/10.1111/j.1365-2141.1994.tb08328.x
Abstract
Flow cytometry was used to determine the percentage and number of circulating CD34+ cells in fetal blood from 100 pregnancies at 13-38 weeks gestation. When expressed as a percentage of the total number of lymphocytes, the proportion of CD34+ cells decreased exponentially from a mean of 11.1% (9.2 x 107/1) at 13 weeks to 1.0% (3.0 x 107/1) at 38 weeks (r = 0.751, P < 0.0001. The use of primitive fetal blood CD34+ progenitor cells for prenatal somatic gene therapy may have distinct advantages over postnatal somatic gene therapy.Keywords
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