5β-Reduced Neuroactive Steroids Are Novel Voltage-Dependent Blockers of T-Type Ca2+ Channels in Rat Sensory Neurons in Vitro and Potent Peripheral Analgesics in Vivo
- 1 November 2004
- journal article
- Published by Elsevier in Molecular Pharmacology
- Vol. 66 (5) , 1223-1235
- https://doi.org/10.1124/mol.104.002402
Abstract
T-type Ca2+ channels are believed to play an important role in pain perception, and anesthetic steroids such as alphaxalone and allopregnanolone, which have a 5α-configuration at the steroid A, B ring fusion, are known to inhibit T-type Ca2+ channels and cause analgesia in a thermal nociceptive model (Keywords
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