Comparison of measured exhaled nitric oxide at varying flow rates
Open Access
- 1 September 2005
- Vol. 60 (9) , 788
- https://doi.org/10.1136/thx.2005.045468
Abstract
A number of factors can influence the production and measurement of FeNO including airway calibre, caffeine, smoking and, in particular, respiratory flow rate. A standardised flow rate of 50 ml/s has recently been adopted by both the European Respiratory Society and the American Thoracic Society; however, to date, there has been a discrepancy in the rates used by clinicians and researchers worldwide.4 The Logan LR 2000 chemiluminescence analyser (Logan Research Ltd, UK) uses a mouth flow rate of 250 ml/s to measure FeNO while the Niox® Nitric Oxide Analyzer (Aerocrine AB, Sweden) uses a flow rate of 50 ml/s. Both analysers use online measurements to calculate FeNO, express the results in parts per billion (ppb), and have similar accuracies.Keywords
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