A Mathematical Model for Estimation of Plutonium in the Human Body from Urine Data Influenced by DTPA Therapy

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Abstract
An empirical urinary excretion model was derived from two puncture wound cases and several inhalation cases treated with DTPA. Important excretion mechanisms for chelated plutonium and the chemistry of plutonium under physiological conditions are related to the derivation of mathematical models for single and multiple DTPA treatments. hese models are used as a basis for assessing plutonium body burdens after DTPA therapy, determining the optimal DTPA dosage regimen, and evaluating the effectiveness of DTPA therapy. DTPA therapy initiated immediately after a contamination ncident will reduce a body burden by a factor of about three. A larger fraction of plutonium loosely deposited in body tissues can be removed by prolonged therapy. An inhalation incident involving six workers in a 238Pu oxide production facility is discussed. Worker bioassay data are compared with urinary excretion rates predicted by the Pu-DTPA model.

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