Synthesis of 26,27-dialkyl analogues of 1.ALPHA.,25-dihydroxyvitamin D3.

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Abstract
1.alpha.,25-Dihydroxy-26,27-dimethylvitamin D3 (5), 1.alpha.,25-dihydroxy-26,27-diethylvitamin D3 (6), 25-hydroxy-26,27-dimethylvitamin D3 (7), and 1.alpha.-hydroxy-26,27-dimethylvitamin D3 (8), as dialkyl analogues of 1.alpha.,25-dihydroxyvitamin D3 (1), were synthesized starting from 3.beta.-hydroxycholenic acid (9). When tested for ability to increase serum calcium concentration in rats, 5 was slightly less active than 1, whereas 6 was much less active. Compound 8 was less active than 1.alpha.-hydroxyvitamin D3. In test for ability to induce cell differentiation of HL-60, 5 was 2.5 times and 6 was 12.5 times more active than 1.