SULFONAMIDE RESISTANCE DEVELOPING DURING TREATMENT OF PNEUMOCOCCIC ENDOCARDITIS

30 May 1942

journal article
research article
Published by American Medical Association (AMA)

Vol. 119 (5) , 409-411
https://doi.org/10.1001/jama.1942.72830220001009

Abstract

An important question raised by recent investigations of the sulfonamide drugs concerns the development of sulfonamide-resistant organisms during treatment of clinical infections. Experimental studies, both in vivo and in vitro,¹have shown conclusively that sulfonamide-sensitive pneumococci can be readily converted into organisms that are highly resistant to these drugs. Available reports²suggest that this may also occur during use of the sulfonamides in treating human infections. During a study of the clinical aspects of this problem in our laboratories a case of pneumococcic endocarditis was encountered which proved to be of special interest. The pneumococci isolated from this case at progressive intervals during treatment showed as great a change in sulfonamide sensitivity as has been produced experimentally¹and a greater change than has been reported in any clinical case heretofore.²The observations on this case are summarized here. REPORT OF CASE History.— A Negro woman

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