ACUTE RENAL TUBULAR DYSFUNCTION FOLLOWING CIS-DICHLORODIAMMINE PLATINUM THERAPY
- 1 January 1980
- journal article
- research article
- Vol. 11 (2-3) , 133-141
Abstract
Following single, high dose (3 mg/kg) DDP [cis-dichlorodiammine platinum] therapy, 7 patients with head and neck cancer developed significant serum electrolyte disturbances. Hypocalcemia, hypomagnesemia, hypokalemia and hypophosphatemia were the most clinically significant electrolyte abnormalities. Renal clearance studies support a pathologic mechanism of a diffuse renal tubular leakage not associated with renal failure.This publication has 4 references indexed in Scilit:
- Platinum nephrotoxicityThe American Journal of Medicine, 1978
- Long term effect of Cis-Diamminedichloride platinum (CDDP) on renal function and structure in manCancer, 1978
- Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular CancerAnnals of Internal Medicine, 1977
- PREVENTION OF RENAL-FAILURE IN RATS RECEIVING CIS-DIAMMINEDICHLOROPLATINUM(II) BY ADMINISTRATION OF FUROSEMIDE1977