THE EFFECT OF DOSAGE AND DURATION OF ADMINISTRATION ON THE ANTI-UREMIC EFFECT OF DESOXYCORTICOSTERONE

31 July 1941

journal article
research article
Published by American Physiological Society in American Journal of Physiology-Legacy Content

Vol. 134 (1) , 71-73
https://doi.org/10.1152/ajplegacy.1941.134.1.71

Abstract

Desoxycorticosterone acetate exerts a protective effect in exptl. uremia produced by complete nephrec-tomy and although it does so when given in ranging doses and for different periods of time, the optimum conditions for the study of these antiuremic properties are 2.0 mg./day in the 18 g. mouse, and 5 mg./day in the 95 g. rat given subcut. in oil for 3 days.

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