Endothelium-derived relaxing factor (EDRF)
- 1 December 1985
- journal article
- review article
- Published by Springer Nature in Inflammation Research
- Vol. 17 (2) , 181-183
- https://doi.org/10.1007/bf01966589
Abstract
Recent studies on endothelium-dependent vasorelaxation have been briefly reviewed and analyzed. The following processes appear to subserve this mechanism:In the endothelial cell: receptor activation, activation of phospholipases, mobilization of intracellular Ca2+, synthesis and release of ‘endothelium-derived relaxing factor(s) (EDRF);In the smooth muscle cell: activation of guanyl cyclase and protein kinase, protein phosphorylation/dephosphorylation, relaxation. Alterations of this mechanism could be involved in certain cardiovascular disorders.This publication has 15 references indexed in Scilit:
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