Ampicillin Hypersensitivity in Lymphatic Leukaemia

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Abstract
Skin rashes developed during ampicillin therapy in 10 of 12 patients with lymphatic leukaemia. This apparent susceptibility to ampicillin is similar to that previously described in patients with infectious mononucleosis. It is postulated that patients with lymphatic leukaemia and infectious mononucleosis have an alteration in immune response due to abnormal lymphocytic function. It is suggested that, in these patients with bacterial infection, initial antibiotic treatment should not include ampicillin.