Thrombocytopenia as a laboratory sign and complication of gram-negative bacteremic infection

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Abstract
Reports of six cases of thrombocytopenia occurring with gram-negative bacteremic infection have been summarized. In one case 51Cr lifespan data suggested that peripheral platelet destruction may have accounted for the thrombocytopenia that was observed. In addition, persistent granulocytosis, sometimes of marked degree, was noted in several cases during sustained thrombocytopenic intervals. The possible mechanisms for a divergent granulocyte and platelet response in gram-negative bacil-lary sepsis, as well as the possible mechanisms for bacterial or en-dotoxin-induced platelet destruction, have been discussed.