Effect of Synthetic and Biological Polyanions on Herpes Simplex Virus.

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Abstract
Summary Several synthetic and biological sulfated polymers were investigated for their inhibitory effect on herpes simplex virus in tissue culture. Of the biological preparations tested, heparin was the only one which inhibited this virus. Nineteen other sulfated polymers were assayed and found to inhibit herpes simplex to varying degrees. The inhibitory potency of the compound depended within limits on the degree of sulfation and on the size of the molecule. The viral inhibitory effect was independent of the polysac-charide portion or branching of the molecule, and of the type of glycosidic or sulfur bond.