Liver Biopsy in Hemophilia A

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Abstract
Hepatitis is a significant complication of the treatment of hemophilia A with factor VIII concentrates. Chronic liver disease in these patients is infrequently documented in the literature. The results of percutaneous liver biopsy, under the coverage of glycine-precipitated factor VIII, in 6 patients with hemophilia A who had the persistence of abnormal liver-function tests for at least 6 mo., are described. Three patients had chronic active hepatitis and 3 had chronic persistent hepatitis. No complications were encountered as a result of the biopsy procedure. Percutaneous liver biopsy should be considered in patients with hemophilia A with continuously abnormal liver-function tests to establish a histologic diagnosis and to guide further therapy.