Aqueous One-Pot Synthesis of Derivatized Cyclopentadienyl-Tricarbonyl Complexes of99mTc with an In Situ CO Source: Application to a Serotonergic Receptor Ligand

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Abstract
Instant radiopharmaceuticals—just add [99mTcO4]− in water! Half-sandwich complexes of the type [(RCOCp)99mTc(CO)3] (e.g. 1) were synthesized in a single step in water from [99mTcO4]−. The acidification of the Cp ring by a carbonyl substituent and the use of K2[H3BCO2] as a reducing agent and in situ source of CO are instrumental in the synthesis.