Changes in food and water intake associated with an interruption of the anterior or posterior fiber connections of the hypothalamus.

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Abstract
Studied the effects of transverse knife cuts which interrupted posterior fiber connections of the medial hypothalamus without producing significant cellular destruction in 30 female Sprague-Dawley rats. Hyperphagia and hyperdipsia resulted. Both effects were most pronounced during the 1st 2 wk. after surgery, but food as well as water intake remained significantly elevated 6 wk. after the cuts were made. Similar transverse cuts through the anterior hypothalamus, just anterior to the ventromedial nuclei, also produced hyperphagia and hyperdipsia. In most Ss these effects were transient. Average food intake returned to near-normal levels within 2 wk. and water intake declined to below-normal levels after 4 wk. 3 Ss with anterior cuts which did not appear to involve the ventromedial nuclei directly remained hyperphagic and hyperdipsic. (18 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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