Psychotropic drugs and depressive syndrome in schizophrenia

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Abstract
Lifelong records of schizophrenic illnesses were examined in order to compare the occurrence and characteristics of depressive syndrome in the pre-phenothiazine era and with neuroleptic treatments. It was found that a depressive syndrome similar to endogenous depressive psychosis develops spontaneously and independently of neuroleptic medication. The relationship of this endogenous syndrome to the postpsychotic depression of other origin is discussed.