Effect of Adrenocortical Hormones on Presence of C-reactive Protein in Blood.

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Abstract
Following single intravenous injection of typhoid vaccine, C-reactive protein usually appears in the blood within 6 to 12 hours, reaches maximum levels within 24 to 48 hours and persists for 4 to 5 days. Administration of cortisone., aspirin or ACTH failed to alter significantly the promptness, intensity or duration of the C-reactive protein response in any of the 9 patients studied. Cx-reactive protein appeared in the blood of rabbits within 12 to 18 hours after the intradermal in-jection of live pneumococci and persisted in all surviving animals within the 4 day period of the experiment. Administration of cortisone or ACTH to rabbits did not appear to influence significantly the Cx-reactive protein response to the experimental infection. The experimental results support the clinical impression that the disappearance of C-reactive protein from human blood during antirheumatic therapy with adrenocortical hormones or with salicylates is secondary to suppression of the inflammatory process rather than a primary effect of these agents upon the metabolism of the C-reactive protein.

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