The in Vitro Transfer of Delayed Hypersensitivity to Rhesus Monkey and Human Lymphocytes with Transfer Factor Obtained from Rhesus Monkey Peripheral White Blood Cells

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Abstract
Transfer factor activity has been demonstrated in the non-dialyzable portion of the peripheral white blood cell lysates of rhesus monkeys sensitized to keyhole limpet hemocyanin (KLH). The transfer factor is capable of “sensitizing” rhesus monkey lymphocytes in vitro so that they are stimulated by KLH to increased incorporation of tritiated thymidine. The factor is also capable of sensitizing human lymphocytes. Lymphocytes from KLH-sensitive monkeys upon stimulation with KLH show peak thymidine incorporation between 3 and 6 days. Lymphocytes sensitized with transfer factor show no stimulation to KLH at 3 days and in some experiments no stimulation is observed before 6 days. Human lymphocytes incubated with the transfer factor and KLH do not show increased thymidine incorporation before 9 days.

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