Preparation and evaluation of ethylcellulose microcapsules with bacampicillin

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Abstract
Ethylcelluloses of different types were used to microencapsulate bacampicillin. Polymer deposition from cyclohexane was performed by temperature change. As coacervation - inducing agent different polyisobutylenes (Oppanol B - 200, B - 100, B - 50, B -3) were used. Fine products with slower drug release were obtained. Average diameters of prepared microcapsules were determined with sieve analysis and it was shown that the particle size of the microcapsules follows log - normal distribution. Scanning electron microscopy was used to examine the shape and the surface characteristics of the microcapsules. HPLC method was developed for testing drug content and its dissolution. Drug content in the microcapsules was in all cases over 80% regarding the amount added. Dissolution of bacampicillin from microcapsules was retarded comparing to the dissolution of bacampicillin itself. The experimental values of dissolution were fitted with different model kinetics. To describe the dissolution profiles we suggested the combined zero and first order kinetics. The bitter taste was quite satisfactory disguised in all prepared microcapsules.

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