Inhaled Nitric Oxide Versus Intravenous Vasodilators in Severe Pulmonary Hypertension After Cardiac Surgery
- 1 November 1999
- journal article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 89 (5) , 1108-1115
- https://doi.org/10.1213/00000539-199911000-00007
Abstract
In a prospective, randomized crossover study of inhaled nitric oxide (iNO) versus IV vasodilators, performed in adult patients with severe pulmonary hypertension but preserved right ventricular function after cardiac surgery, iNO was not superior to IV prostaglandin E1 with regard to cardiac index and right ventricular performance. Considering the potential toxicity of iNO, better definition of patient subsets with a positive benefit/risk ratio is warranted.Keywords
This publication has 22 references indexed in Scilit:
- Adenosine effectively controls pulmonary hypertension after cardiac operationsThe Annals of Thoracic Surgery, 1996
- Inhaled Nitric Oxide Improves Hepatic Tissue Oxygenation in Right Ventricular FailureAnesthesiology, 1995
- Hemodynamic effects of inhaled nitric oxide in heart failureJournal of the American College of Cardiology, 1994
- Inhaled nitric oxide leading to pulmonary edema in stable severe heart failureThe American Journal of Cardiology, 1994
- Inhaled Nitric Oxide after Mitral Valve Replacement in Patients with Chronic Pulmonary Artery HypertensionAnesthesiology, 1992
- Vasodilator Therapy in Microembolic Porcine Pulmonary HypertensionAnesthesia & Analgesia, 1990
- Prostaglandin E1 and Nitroglycerin Reduce Pulmonary Capillary Pressure but Worsen Ventilation—Perfusion Distributions in Patients with Adult Respiratory Distress SyndromeAnesthesiology, 1989
- Vasodilator Therapy in Vasoconstrictor-induced Pulmonary Hypertension in SheepAnesthesiology, 1988
- Intravenous Glyceryl Trinitrate (Nitroglycerin) A Review of its Pharmacological Properties and Therapeutic EfficacyDrugs, 1984
- Inactivation of Prostaglandins by the LungsNature, 1970