Corticosteroid Therapy

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Abstract
SINCE cortisone and corticotropin first became available more than 25 years ago, these agents, and particularly the newer synthetic corticosteroids, have established an important place for themselves in the therapy of a wide variety of disorders falling within the purview of virtually every branch of medical practice. Surprisingly, however, there is still uncertainty about the role of steroid therapy in several specific disease states. There are also some important recent advances of a practical nature that make it worthwhile to review the modern use of steroid therapy in clinical practice. PHARMACOLOGICAL PROPERTIES Corticosteroids have widely differing actions on the tissues and fluids of the body, and many of their effects may be considered therapeutically valuable in one patient and unwarranted side effects in another. Thus, the effect of raising blood glucose levels may be an important reason for using a glucocorticoid in a patient with adrenal insufficiency or, temporarily, in

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