A New Synthesis of 1,1-Difluoro-1,3-dienes via the Coupling Reaction of 2,2-Difluorovinylboranes
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (09) , 739-740
- https://doi.org/10.1055/s-1992-21475
Abstract
2,2,2-Trifluoroethyl p-toluenesulfonate (1) is treated successively with butyllithium and trialkylboranes to generate 1-alkyl-2,2-difluorovinylboranes 3 which in turn undergo stereospecific coupling reactions with 1-alkenyl halides in the presence of copper(I) iodide and a palladium catalyst to afford 1,1-difluoro-1,3-dienes 4 in good yields.Keywords
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