Observations on the Action of Prednisolone Tertiary Butyl Acetate (Codelcortone TBA) and Methylprednisolone Acetate (Depomedrone) on Normal Soft Tissues

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Abstract
Summary The actual influence of locally administered steroids on the various tissue elements has not yet been fully understood. Their inhibitory effect on inflammation has led many to believe that they may ultimately cause local tissue necrosis. To test the validity of this postulate some common steroid preparations for local use have been evaluated by vital microscopic and histologic techniques. Steroid preparations and their suspension media were deposited between the two layers of hamster cheek pouches, on exposed rabbit mesentery and subperichondrally in rabbit's ears. It soon became evident that for one commonly used preparation (Codelcortone TBA) a particular component of the suspension medium, namely sorbitol, had a deleterious effect on microcirculatory events and on individual tissue elements. The other tested substance (Depomedrone) did not show any such adverse effects as its suspension medium does not contain any sorbitol. The pure steroid powder suspended in saline had no damaging effect on the microcirculation nor the extravascular tissues.

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